comparative toxicokinetic/toxicodynamic study of rubber
Comparative toxicokinetic/toxicodynamic study of rubber
2-Mercaptobenzimidazole (MBI), a rubber antioxidant, is known to exhibit potent thyroid toxicity in rats, whereas its methylated derivatives are much less toxic. To characterize this methyl-substituent effect on the thyroid toxicity of MBI, comparative toxicokinetic analyses have been conducted in the present study.
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Comparative toxicokinetic/toxicodynamic study of rubber
2-Mercaptobenzimidazole (2-MBI), a rubber antioxidant, is known to exhibit potent antithyroid toxicity in rats and is a candidate as an environmental endocrine disrupter. 2 ...
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Comparative toxicokinetic study of rubber
Comparative toxicokinetic study of rubber antioxidants, 2- mercaptobenzimidazole and 2-mercaptomethylbenzimidazole, by single oral administration in rats
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Comparative toxicokinetic study of rubber antioxidants, 2
Comparative toxicokinetic study of rubber antioxidants, 2-mercaptobenzimidazole and 2-mercaptomethylbenzimidazole, by single oral administration in rats. [K Sakemi, M Usami, K Mitsunaga, Y Ohno, M Tsuda]
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Fundamental Toxicological Sciences - JST
(1999): Comparative toxicokinetic study of rubber antioxidants, 2-mercaptobenzimidazole and 2-mercaptomethylbenzimidazole, by single oral administration in rats. J. Toxicol.
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Environmentally-Relevant Mixtures in Cumulative
Description: Studies of pyrethroid neurotoxicity suggest a common mode of toxicity and that pyrethroids should be considered cumulatively to model risk. The objective of this work was to use a pyrethroid mixture that reflects human exposure to common pyrethroids to develop comparative toxicokinetic profiles in rats,...
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Molecular Interaction Mechanism between 2
Abstract. 2-Mercaptobenzimidazole (MBI) is widely utilized as a corrosion inhibitor, copper-plating brightener and rubber accelerator. The residue of MBI in the environment is potentially harmful. In the present work, the toxic interaction of MBI with the important antioxidant enzyme copper-zinc superoxide dismutase (Cu/ZnSOD)...
Send InquiryDemographic Toxicokinetic–Toxicodynamic Modeling of Lethal
Toxicokinetic-toxicodynamic (TK-TD) models simulate the processes that lead to toxicity at the level of organisms over time. These dynamic simulation models quantify toxicity, but more importantly they also provide a conceptual framework to better understand the causes for variability in different species' sensitivity to the same compd. as well as causes for different toxicity of different compds. to the same species.
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Ketamine analogues: Comparative toxicokinetic in vitro–in
In the current study, all ketamine analogues exhibited prolonged metabolic half-lives in pHLM, although the toxicodynamic profiles were not assessed. The toxicodynamic effect of the analogue and metabolite NK is reported to be similar to that of ketamine , and the same is also postulated for normethoxetamine . These reported varying toxicodynamic profiles and the documented reduced clearance for NK, 2FDCK, DCK and MXE elucidate the toxicokinetic relations of ketamine analogues.
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CiNii 論文 - COMPARATIVE TOXICOKINETIC STUDY OF RUBBER
comparative toxicokinetic study of rubber antioxidants, 2-mercaptobenzimidazole and 2-mercaptomethylbenzimidazole, by single oral administration in rats Sakemi Kazue SAKEMI Kazue Division of Pharmacology, Biological Safety Research Center, National Institute of Health Sciences
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Comparative toxicokinetic/toxicodynamic study of rubber
2-Mercaptobenzimidazole (MBI), a rubber antioxidant, is known to exhibit potent thyroid toxicity in rats, whereas its methylated derivatives are much less toxic. To characterize this methyl-substituent effect on the thyroid toxicity of MBI, comparative toxicokinetic analyses have been conducted in the present study.
Send InquiryComparative toxicokinetic/toxicodynamic study of rubber
Comparative toxicokinetic/toxicodynamic study of rubber antioxidants, 2-mercaptobenzimidazole and its methyl substituted derivatives, by repeated oral administration in rats
Send InquiryComparative toxicokinetic study of rubber
Comparative toxicokinetic/toxicodynamic study of rubber antioxidants, 2-mercaptobenzimidazole and its methyl substituted derivatives, by repeated oral administration in rats
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Comparative toxicokinetic study of rubber antioxidants, 2
Comparative toxicokinetic study of rubber antioxidants, 2-mercaptobenzimidazole and 2-mercaptomethylbenzimidazole, by single oral administration in rats. [K Sakemi, M Usami, K Mitsunaga, Y Ohno, M Tsuda]
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1,3-dihydro-4(or... - Registration Dossier - ECHA
Comparative toxicokinetic/toxicodynamic study of rubber antioxidants, 2-mercaptobenzimidazole and its methyl substituted derivatives, by repeated oral administration in rats Author: Sakemi K, Ito R, Umemura T, Ohno Y, Tsuda M
Send InquiryKetamine analogues: Comparative toxicokinetic in vitro–in
In the current study, all ketamine analogues exhibited prolonged metabolic half-lives in pHLM, although the toxicodynamic profiles were not assessed. The toxicodynamic effect of the analogue and metabolite NK is reported to be similar to that of ketamine , and the same is also postulated for normethoxetamine . These reported varying toxicodynamic profiles and the documented reduced clearance for NK, 2FDCK, DCK and MXE elucidate the toxicokinetic relations of ketamine analogues.
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Molecular Interaction Mechanism between 2
Abstract. 2-Mercaptobenzimidazole (MBI) is widely utilized as a corrosion inhibitor, copper-plating brightener and rubber accelerator. The residue of MBI in the environment is potentially harmful. In the present work, the toxic interaction of MBI with the important antioxidant enzyme copper-zinc superoxide dismutase (Cu/ZnSOD)...
Send InquiryToxicodynamics - an overview | ScienceDirect Topics
Toxicokinetic (TK)—toxicodynamic (TD) modeling describe quantitative estimations of expected dose-response relationships by the use of TK/TD data. Early contributions to this field that used data on cadmium were those published by Nordberg and Strangert (1985), described and discussed in more detail in Chapter 23.
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