prenatal developmental toxicity study of the basic rubber
Prenatal developmental toxicity study of the basic rubber
Prenatal developmental toxicity study of the basic rubber accelerator, 1,3-di-o-tolylguanidine, in rats Author links open overlay panel Makoto Ema a Sakiko Fujii b Mariko Matsumoto a Akihiko Hirose a Eiichi Kamata a
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Prenatal developmental toxicity study of the basic rubber
Prenatal developmental toxicity study of the basic rubber accelerator, 1,3-di-o-tolylguanidine, in rats Article in Reproductive Toxicology 22(4):672-8 ยท December 2006 with 5 Reads
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Prenatal developmental toxicity study of n-heneicosane
Prenatal developmental toxicity study of n-heneicosane in Wistar rats Pravin Kumar, Vinay Lomash, PC Jatav, A Kumar, and SC Pant Toxicology and Industrial Health 2013 32 : 1 , 118-125
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Prenatal development toxicity study of zinc oxide
Conclusion. The results of this developmental toxicity study suggest that administration of ZnO SM20 (+) NPs to pregnant rats had minimal impact on intrauterine fetal growth and development, even in the high dose of 400 mg/kg/day. Based on the results of these studies, a dosage level of 200 mg/kg/day of ZnO SM20...
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Evidence for a Role of Paternal Exposures in Developmental
Prenatal exposure during the embryonic development of the male reproductive system. In 2005, Anway et al. published a startling report showing that consequences of exposure of pregnant rats to relatively high levels of the insecticide methoxychlor and the fungicide vinclozolin lasted for four subsequent generations with the same magnitude. It affected mostly males showing an impact on fertility, prostate and kidney disease and immune abnormalities.
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Reproductive and developmental toxicity screening test
This study concluded that orally administered EPL is safe to rats during embryonic development. View Show abstract Prenatal developmental toxicity study of the basic rubber accelerator, 1,3-di-o ...
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Chapter 24 Children and Adolescents Flashcards
toxicity associated with maternal ingestion of alcohol or other drugs ... impoverished envrionments associated with poor prenatal and perinatal care and inadequate nutrition ... persistent pattern of behavior in which the basic rights of others and major age appropirate societal norms or rules are violated
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[Full text] Prenatal development toxicity study of zinc
Prenatal development toxicity study of zinc oxide nanoparticles in rats. However, no treatment-related difference in: number of corpora lutea; number of implantation sites; implantation rate (%); resorption; dead fetuses; litter size; fetal deaths and placental weights; and sex ratio were observed between the groups.
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Reproductive and Developmental Toxicity
Developmental toxicity pertains to adverse toxic effects to the developing embryo or fetus. Chemicals cause developmental toxicity by two ways. They can act directly on cells of the embryo or fetus causing cell death or cell damage, leading to abnormal organ development. A chemical might also induce a mutation in a parent's germ cell which is transmitted to the fertilized ovum. Some mutated fertilized ova develop into abnormal embryos. The 3 basic types of developmental toxicity are shown in ...
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Nonclinical Safety Assessment of Developmental
7 Reproductive and Developmental Toxicity Evaluations in the Nonhuman Primate. Potential effects on male and female fertility can be assessed by histopathologic evaluation, assessment of menstrual cycling and sperm assessments including evaluation of motility, morphology, sperm counts, and testicular size.
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Prenatal developmental toxicity study of the basic rubber
A significantly decreased weight of the gravid uterus, increased incidence of postimplantation loss, decreased number of live fetuses, andThe data indicate that DTG is teratogenic at maternal toxic doses and the NOAELs of DTG for maternal and developmental toxicity are 10 mg/kg bw/day in rats.
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Prenatal developmental toxicity study of the basic rubber
Reproductive and developmental toxicity screening test of basic rubber accelerator, 1,3-di-o-tolylguanidine, in rats.Twelve male and female rats per group were exposed to the rubber accelerator 1,3-di-o-tolylguanidine (DTG) by gavage at 0, 8, 20 or 50 mg/kg bw/day.
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OECD iLibrary | Test No. 414: Prenatal Developmental Toxicity Study
This Test Guideline for developmental toxicity testing is designed to provide general information concerning the effects of prenatal exposure on theIn any study which demonstrates an absence of toxic effects, further investigation to establish absorption and bioavailability of the test substance
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Health Effects Test Guidelines OPPTS 870.3700 Prenatal
Guidelines. OPPTS 870.3700. Prenatal Developmental. Toxicity Study.(b) Purpose. This guideline for developmental toxicity testing is designed to provide general information concerning the effects of exposure of the pregnant test animal on the developing organism; this may include death, structural
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Reproductive and Developmental Toxicity
Developmental toxicity pertains to adverse toxic effects to the developing embryo or fetus. Chemicals cause developmental toxicity by two ways. They can act directly on cells of the embryo or fetus causing cell death or cell damage, leading to abnormal organ development. A chemical might also
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Blood Donation; a Risk for Prenatal Developmental Toxicity?
Blood Donation Medicinal Product Developmental Disorder Developmental Toxicity Reproductive Toxicity.Cite this chapter as: Peters P.W.J. (2002) Blood Donation; a Risk for Prenatal Developmental Toxicity?. In: Sibinga C.T.S., Dodd R.Y. (eds) Transmissible Diseases and Blood
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Developmental toxicity Research Papers - Academia.edu
View Developmental toxicity Research Papers on Academia.edu for free.These three endpoints were applied to a prediction model developed during a validation study of the European Centre for the Validation of Alternative Methods (ECVAM) allowing the classification of the embryotoxic potential of
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Developmental Toxicity - an overview | ScienceDirect Topics
Developmental toxicity is defined as the study of adverse effects on the developing organism that may result from exposure prior to conception (either parent), during prenatal development, or postnatally to the time ofThe basic scheme of vertebrate development is illustrated in Figure 11.18.
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Historical control data on prenatal developmental toxicity studies
Japanese White rabbits and New Zealand White rabbits were used for prenatal developmental toxicity studies. The data included maternal reproductiveIn this paper, data were incorporated from a laboratory if the information was based on 10 studies or more. Japanese White rabbits and New
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Reproductive & Developmental Toxicity | AltTox.org
Reproductive toxicity includes the toxic effects of a substance on the reproductive ability of an organism and theThe definitive animal test for evaluating potential developmental toxicity is the prenatalTherefore, a new test design called the extended one-generation reproductive toxicity studyDevelopmental toxicity is one of the most animal-intensive areas of regulatory toxicology
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