metabolic dephenylation of the rubber antioxidant on malaysia
Metabolic dephenylation of the rubber antioxidant N
N-Phenyl-2-naphthylamine (P2NA) was widely used as oxidation inhibitor, particularly in rubber manufacturing. Technical-grade P2NA was contaminated with carcinogenic 2-naphthylamine (2NA), and bladder cancer risk in exposed workers was attributed to this impurity. Investigations in humans and mammalian species revealed that small amounts of 2NA are excreted into urine after exposure to P2NA.
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Metabolic dephenylation of the rubber antioxidant N
Metabolic dephenylation of the rubber antioxidant N-phenyl-2-naphthylamine to carcinogenic 2-naphthylamine in rats Article (Available) in Archives of Toxicology 87(7) · February 2013 with 30 ...
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Metabolic dephenylation of the rubber antioxidant N-phenyl
Metabolic dephenylation of the rubber antioxidant N-phenyl-2-naphthylamine to carcinogenic 2-naphthylamine in rats. [Tobias Weiss, Hermann M Bolt, Gerhard Schlüter, Stephan Koslitz, Dirk Taeger, Peter Welge, Thomas Brüning]
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Metabolic dephenylation of the rubber antioxidant N
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Send InquiryMetabolic dephenylation of the rubber antioxidant N ... - CORE
Metabolic dephenylation of the rubber antioxidant N-phenyl-2-naphthylamine to carcinogenic 2-naphthylamine in rats By Tobias Wei\udf, Hermann M. Bolt, Gerhard Schl\ufcter, Stephan Koslitz, Dirk Taeger, Peter Welge and Thomas Br\ufcning
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Carcinogenicity of /V-Phenyl-1-naphthylamme and JV-Phenyl
other routes of metabolic activation besides dephenylation for both chemicals in mice. INTRODUCTION After confirmation of the carcinogenicity of PBNA2 in animals, its optic isomer, PANA, was tested for its carcinogenicity in comparison with that of PBNA in 2 animal models (7-11). It was found that PANA, also an antioxidant used in the rubber industry,
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Dephenylation of the Rubber Chemical N -Phenyl-2
To explain the metabolic dephenylation process, it has been suggested that PBNA is metabolized by cytochrome P-450 (CYP) enzymes to the phenolic derivative 4'-hydroxy-N-phenyl-2-naphthylamine ...
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2-NAPHTHYLAMINE - Chemical Agents and Related Occupations
2-Naphthylamine formerly was used commercially as an intermediate in the manufacture of dyes, as an antioxidant in the rubber industry, and to produce 2-chloronaphthalene . Because of its carcinogenicity, the manufacture and use of 2-naphthylamine have been prohibited in the European Union (EU) since 1998, in Italy since 1960, in the United Kingdom since 1952, and in Switzerland since 1938.
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Original article - sjweh.fi
body by metabolic dephenylation of the antioxidant phenyl (3-naphthylamine, which is still in production. The quantities which may be produced by metabolic dephenylation are shown in table 10. It should be pointed out that there is strong epidemiologic evidence that the use of phenyl P-naphthylamine in industry has
Send InquiryComparative N-dephenylation of N-phenyl-2-naphthylamine
Introduction N-phenyl-2-naphthylamine (CAS number, 135886, PBNA) is used as a stabilizing agent and an antioxidant for various lubricant and transformer oilsI-3. It is also used in plastic and rubber industries as a polymeriza- tion inhibitor and a vulcanization acceleratorI-3.
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Metabolic dephenylation of the rubber antioxidant
N-Phenyl-2-naphthylamine (P2NA) was widely used as oxidation inhibitor, particularly in rubber manufacturing. Technical-grade P2NA wasAn experimental animal study was therefore designed to indicate if, and if yes to which extent, 2NA from P2NA dephenylation is accessible to the metabolic
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Metabolic dephenylation of the rubber antioxidant | Sigma-Aldrich
N-Phenyl-2-naphthylamine (P2NA) was widely used as oxidation inhibitor, particularly in rubber manufacturing. Technical-grade P2NA was contaminated with carcinogenic 2-naphthylamine (2NA), and bladder cancer risk in exposed workers was attributed to this impurity.
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Metabolic dephenylation of the rubber antioxidant
Request on ResearchGate | Metabolic dephenylation of the rubber antioxidant N-phenyl-2-naphthylamine to carcinogenic 2-naphthylamine in ratsAn experimental animal study was therefore designed to indicate if, and if yes to which extent, 2NA from P2NA dephenylation is accessible to the
Send InquiryMetabolic dephenylation of the rubber antioxidant
N-Phenyl-2-naphthylamine (P2NA) was widely used as oxidation inhibitor, particularly in rubber manufacturing. Technical-grade P2NA wasAn experimental animal study was therefore designed to indicate if, and if yes to which extent, 2NA from P2NA dephenylation is accessible to the metabolic
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Scilit | Article - Metabolic dephenylation of the rubber antioxidant
N-Phenyl-2-naphthylamine (P2NA) was widely used as oxidation inhibitor, particularly in rubber manufacturing. Technical-grade P2NA was contaminated with
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Dephenylation of N-phenyl-2-naphthylamine in - Semantic Scholar
Metabolic dephenylation of the rubber antioxidant N-phenyl-2-naphthylamine to carcinogenic 2-naphthylamine in rats.A Survey of Occupational Cancer in the Rubber and Cablemaking Industries : Results of Five - year Analysis , 1967 - 1971.
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Effect of Myoinositol and Antioxidants on Sperm Quality in Men
Hormone and metabolic profiles and semen parameters were assessed at the beginning of the study and after three months of treatment with Andrositol. The differences between the values before and after the supplementation were found statistically significant.
Send InquiryMetabolic Engineering of the Phenylpropanoid Pathway Enhances the
The potent antioxidant effects of these compounds are responsible for anti-inflammatory, antimutagenic and anti-tumor activities [1]–[3]. OurThe transcriptome data of S. involucrata obtained in this study can push forward the efforts for the metabolic engineering of medicinal plants in terms of
Send InquiryAntioxidant and anti-inflammatory activity of Ocimum labiatum extract
A battery of antioxidant assays were used for detecting antioxidant activity while the anti-inflammatory mechanism was evaluated using an ELISA-based activator protein (AP-1) (c-Jun) assay.Antioxidant effect of the O. labiatum extract (squares) and the isolated compound (triangles).
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Purine metabolism
Purine metabolism refers to the metabolic pathways to synthesize and break down purines that are present in many organisms. Purines are biologically synthesized as nucleotides and in particular as ribotides, i.e. bases attached to ribose 5-phosphate.
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